Imaging the roots of brain disease: Probing micro-vascular pathology by ASL MRI (11047)

Project nummer:

Omschrijving van het onderzoek

Arterioles, capillaries and venules are the smallest vessels of the cerebral vasculature: arterioles control the resistance of and the blood flow within the microvascular bed, capillaries serve as exchange site of oxygen and nutrients, and venules provide the drainage of the deoxygenated blood. Pathological conditions of these vessels are associated with many neurodegenerative disease, like Alzheimer’s Disease and cerebral amyloid angiopathy, and are responsible for a two times higher risk of dementia. However, our knowledge of these conditions is limited, because these vessels are too small to image in vivo by any modality. In the last 10 years the researchers of this project have implemented non-invasive MRI sequences to image brain perfusion by magnetically labeling of the blood in the brain feeding arteries. In this project, this approach will be extended by employing this approach as a preparation module before quantitative MRI sequences. In this way, the MRI scanner will only record signal originating from the smallest vessels, resulting in a much higher sensitivity for detection of microvascular diseases. Separate sequences will be developed that can measure the oxygenation consumption in the brain, amyloid deposition in the arteriolar wall and reliable assessment of white matter hypoperfusion. The developed techniques will be employed in patient with small and large vessel disease.

Gebruikers

No users' committee has been installed, yet.

Projectleider

Dr. ir. Matthias J.P. van Osch
Leids Universitair Medisch Centrum
Radiologie
Albinusdreef 2
2333 ZA Leiden

Status van het project

Startdatum:	Dit project is nog niet gestart
Einddatum:

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