In vivo optical probing of local tissue morphology and physiology using differential pathlenght spectroscopy (RPG.6582)

Project nummer: rpg6582

Omschrijving van het onderzoek

Measurement of the optical properties of tissue has been an important challenge in biomedical science for nearly two decades. Optical properties of tissue may serve to characterize the tissue and can hence be instrumental for the development of low cost, noninvasive medical diagnostic techniques. Up to recently, absolute measurements of local optical properties in vivo were not possible. Historically, in vivo optical properties were extracted from measurements based on diffusion theory, which is a reasonable approximation for highly scattering media, but gives information on large volumes of tissue only. In another STW project (RNN 5316) we have recently developed Differential Path-length Spectroscopy (DPS), a new technique for absolute local optical absorption, scattering and fluorescence measurements in highly scattering tissues. Initial success has been shown clinically for the bronchial tree. At present, the main challenge is to explore the technical possibilities and the possible applications of DPS, so it can be utilised to its full extent.

Gebruikers

Er zijn drie bedrijven bij dit project betrokken.

Projectleider

Dr. A. Amelink

Erasmus Medisch Centrum Rotterdam
Radiotherapie
Dept. of Radiation Oncology

Postbus 2040
3000 CA Rotterdam

Status van het project

Gestart	: 01-03-2005
Einddatum	: 13-09-2009

Trefwoorden

Light propagation in tissues, Medical optics instrumentation, Medische technologie, Noninvasive optical diagnostics for medicine, Optical spectroscopy, Tissue diagnostics.

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