Fast and depth sensitive laser doppler imaging of tissue perfusion (TGT.6443)

Project nummer: tgt6443

Omschrijving van het onderzoek

Laser Doppler flowmetry (LDF) is a non-invasive technique to measure the microvascular blood flow or perfusion in tissue. Laser Doppler perfusion imaging (LDPI) is a specific implementation of laser Doppler flowmetry that measures the perfusion distribution over a certain tissue area. This is currently performed by a scanning beam and point by point perfusion measurements, which consequently leads to imaging times of several minutes. We propose to develop a laser Doppler perfusion imager that produces maps of the microcirculatory red blood cell flux in a large area of tissue (A) within seconds or even much shorter and (B) for various depths under the tissue surface.
Our method utilises the rapidly developing CMOS image sensor technology.
These sensors allow for image acquisition at a very high frame rate.
When the tissue is illuminated by coherent light, each selected pixel will yield information about the Doppler shifts in the tissue location imaged on that pixel, leading to measurement of the local perfusion level. Furthermore, the same CMOS image sensor can be used to make a high resolution photograph of the tissue site, which is essential for interpretation of the perfusion image. The many signals must be processed with extreme efficiency to rapidly extract the Doppler information. Also depth sensitive or even pathlength selective imaging will be pursued by applying specific illumination and detection schemes. This leads to a more quantitative determination of tissue.
We plan to build prototypes with two degrees of complexity. In a first prototype emphasis will be on imaging speed, while a second prototype also features depth discrimination or path length selectivity.
The instrumentation will be tested on various applications in which fast LDPI is relevant, such as the imaging of burns and chronic lesions on locations which are difficult to access.

Gebruikers

Four companies are involved in this project.

Projectleider

Dr.ir. W. Steenbergen

Universiteit Twente
Technische Natuurwetenschappen
Biophysical Engineering

Postbus 217
7500 AE Enschede

Status van het project

Gestart	: 01-01-2005
Einddatum	: 01-01-2008

Trefwoorden

Beeldbewerking, Biomedische technologie, Brandwonden, Dermatologie, Laser Doppler imaging, Lasertechnologie, Medische technologie.

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