Polymeric micelles with transient stability: a novel and highly versatile drug delivery concept (UFA.6110)

Project nummer: ufa6110

Omschrijving van het onderzoek

A new platform technology is developed for the controlled delivery of drugs, using tailor-made micelles which display transient stability. The micelles are composed of a new family of thermosensitive amphiphilic block copolymers that are transformed in vivo by a chemical or enzymatic process. The polymers and the transformation process are designed such that it brings about a change in the polarity of the block copolymers. This will result in the destabilization of the micelles and concomitant release of the contained drug. We focus on the delivery of phthalocyanine derivatives for photodynamic treatment (PDT) of cancer.
Controlled drug delivery at the site of action will diminish the toxicity of the drugs for healthy tissues, will decrease the amount of drug to be administered because of preferred accumulation at the site of action, or will avoid repeated administrations. These aspects are important in terms of cost savings and the compliance for the patient. For these reasons, the market prospects are good and we experience considerable and growing interests in the results of our project from pharmaceutical companies.

Gebruikers

Er zijn vier bedrijven en één andere universiteit bij dit project betrokken.

Projectleider

Dr. C.F. van Nostrum

Universiteit Utrecht
Farmaceutische Wetenschappen
Sectie Biofarmacie

Postbus 80082
3508 TB Utrecht

Status van het project

Gestart	: 01-09-2003
Einddatum	: 07-09-2007

Trefwoorden

Block copolymeren, Drug delivery, Farmacochemie, Fotodynamische therapie, Micellen, Nanotechnologie, Polymeren

Print | Over deze site |

Sitemap | Voorbehoud | Gewijzigd 7-3-2006