The E. coli Hbp autotransporter: a novel platform for live vaccine development and heterologous protein secretion (11640)

Project nummer: 11640

Omschrijving van het onderzoek

There is a growing need to develop vaccines with the potential for global use against infectious diseases. These vaccines should be inexpensive to produce, safe, easy to distribute, efficacious and suitable for oral or intranasal administration. Live attenuated Salmonella strains that carry protective antigens from pathogenic organisms at their cell surface are considered highly promising candidate vaccines. The aim of this project is to modify a bacterial protein secretion system into a versatile platform for display of immunogenic proteins and epitopes at the cell surface of Salmonella. As proof-of-principle we will produce a live multivalent vaccine that will be subjected to initial animal testing to evaluate its immunogenicity and safety. The surface display platform is expected to be versatile and could be used for applications other than vaccine development such as drug discovery and whole cell catalysis (e.g. in bioremediation).

Gebruikers

No user committee has been installed, yet.

Projectleider

Dr. J. Luirink
Vrije Universiteit Amsterdam
Faculteit der Aard- en Levenswetenschappen
Moleculaire Microbiologie
De Boelelaan 1087
1081 HV AMSTERDAM

Status van het project

Startdatum:	Het project is nog niet gestart.
Einddatum:

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