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Novel Antibacterial Compounds and Therapies Antagonizing Resistance (NACTAR)

Financieringsinstrument 
Status 
Gesloten
Opening 
22 mei 2017
Budget 
5.500.000
Deadline 
21 september 2017 - 2:00pm
Call Type 
Open

The Dutch Ministry of Ministry of Health, Welfare and Sport and NWO Domain TTW have jointly commissioned an ambitious research programme on the development of new antibiotics and alternatives to antibiotics. As a result, we present here the Call for Proposals focusing on 'Novel Antibacterial Compounds and Therapies Antagonizing Resistance' (NACTAR). The main goal of the programme is to facilitate research and development of new antimicrobial molecules and alternatives to antibiotics, which should become available for the healthcare system for a fair and affordable price.

Antimicrobial resistance (AMR) is one of the major threats to human health in the 21st century, with some bacterial pathogens acquiring resistance to all clinically available antibiotics. Worldwide, infections caused by multi-drug resistant (MDR) bacteria are now a major cause of morbidity and mortality, and have markedly increased healthcare costs. Consequently, the aim of this program is to discover, develop and exploit new resources for antibiotics and alternatives to antibiotics and to provide a trajectory for their clinical development. The NACTAR program connects to the National Antibiotic Development Platform (NADP), which was established by NCOH, CARES, CeSAM and Immuno Valley with support of the Dutch Ministry of Health, Welfare and Sport (VWS) with the aim of supporting the development of drugs to counter AMR.

The aim of the NACTAR program is to deliver new bioactive compounds and alternatives to antibiotics aimed at curing human infectious diseases caused by MDR bacteria. This includes the use of microbial hosts and methodologies to synthesize new bioactive compounds and semi-synthetic variants, characterization of their antimicrobial activity and their efficacy in infectious disease animal models. We foresee many potential patent applications, and opportunities for small-to-medium enterprises to interact with academia.

Project proposals adhere to the full programme guidelines as defined in the call for proposals.

We recommend all applicants to consult the programme guidelines, including the guide for applicants, before considering the preparation of a (pre)proposal, and to contact the TTW office well ahead of the submission deadline with any questions.

Information event
To provide information on the programme requirements, as well as encourage the submission of proposals and formation of required partnerships, a 'walk in' Information event is scheduled on Wednesday the 7th of June 2017 from 13:00-16:00h CE(S)T at the NWO Domain TTW office (Van Vollenhovenlaan 661, Utrecht). During the event, representatives from NWO Domain TTW will be present to answer questions on the research programme topics and guidelines for applicants. Scientists from academia, knowledge institutions and other relevant stakeholders are hereby cordially invited to join in the event.

Deadline pre-proposals
Pre-proposals (see format below) need to be submitted to NWO Domain TTW before Tuesday 27th of June 2017, 14.00 CE(S)T via email to t.plantinga@nwo.nl. Applications sent to any other email address and/or arriving after the deadline (date and time) will not be considered.

Deadline full proposals
Only proposals that have taken part in the pre-proposal phase, will be accepted at this stage.
Full proposals (see format below) need to be submitted to NWO Domain TTW before Thursday 21st of September 2017, 14.00 CE(S)T via the online application system ISAAC. Applications that were not part of the pre-proposal phase or that are not submitted via ISAAC will not be considered.

Documents

You will be able to find the documents related to the Call for proposals through the following links:

Call for proposals
Form Application - Pre Proposal
Form Application - Full Proposal
Form Financial Planning
Form Data Management
Form Declaration Main Applicant
TTW General conditions (Dutch)
TTW General conditions (English)