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The RESOLVE project

Project nummer 
15354
Deelnemende kennisinstellingen 
Projectleider 
Dr. ir. H.N. Tijssen Universiteit Utrecht
Universitair Medisch Centrum Utrecht
Radiologie, Radiotherapie en Nucleaire Geneeskunde
Type project 
Lopend
Startdatum 
1 april 2016
Einddatum 
31 maart 2022
Programma 
High Tech Systemen & Materialen (HTSM)
Vakgebied 
Biofysica

The RESOLVE project: Enabling MR guided radiothErapy of moving abdominal tumorS and Organs by development of a dense eLement receiVer array and highly undersampled, parallEl MRI

The increased use of x-ray based image guidance in radiotherapy for cancer patients has led to improved care and reduced toxicity. However, tumors cannot be directly visualized as x-rays lack soft tissue contrast. Magnetic resonance imaging (MRI) has the soft tissue contrast required to visualize tumors in soft tissues as well as their surrounding organs, which should be spared from radiation exposure. The potential of MRI to further improve radiotherapy has led us to pursue the integration of a radiotherapy linear accelerator with an MRI scanner, resulting in a hybrid MR-Linac (MRL) device being shortly introduced in clinic.

Unfortunately, MRL treatment of mobile abdominal and thoracic tumors with high mortality (e.g. pancreatic or esophageal tumors) is not yet viable, as MRI currently lacks the quality and speed needed to resolve respiratory induced tumor and organ motion in the abdomen. In this project we will develop new and faster motion resolved MRI methods that provide the means to monitor 3D dose deposition in moving tissue or even lock the radiation beam onto the moving tumor. This unlocks the potential of MRL for radiation treatment of abdominal tumors resulting in more effective radiation treatment and lower toxicity of healthy organs-at-risk.